Colchicine tablets for gout "Qiushuixianjian Pian"

Indications for use: Prevention and treatment of acute gouty arthritis. Composition: Chemical formula: N-(5, 6, 7, 9 - tetrahydrocannabinol -1, 2, 3, 10-methoxy-9-hydroxy-benzofuran[a]heptalene-7-radical) acetamide Molecular formula: C22H25NO6. Molecular weight: 399.44. Directions for use: for oral use, acute stage: adults – 1) 1 mg 3 times a day, the amount can be reduced as symptoms weaken; or 2) 0.5-1.0 mg every 2 hours until symptoms subside or diarrhea or nausea occurs. It is not allowed to take more than 6 mg per day; the drug cannot be taken continuously for 48 hours. Then take 0.5-1.5 mg per day in increments for 7-14 days. Contraindications: patients with bone marrow hyperplasia and hypoplasia, as well as liver and kidney failure, are prohibited from using this drug; use during pregnancy and breastfeeding: this drug can lead to genetic pathologies. Pregnant and breastfeeding women should not use this drug. Side effects: Gastrointestinal tract: in the early stages of taking the drug, abdominal pain, diarrhea, nausea and lack of appetite are often observed, the incidence can reach 80%. Patients with a severe stage may experience dehydration, electrolyte imbalance, and other symptoms. Patients taking the drug for a long time may experience hemorrhagic gastroenteritis and malabsorption syndrome. Pathological changes in muscles, peripheral nerves: proximal myasthenia and (or) increased serum creatine kinase levels. Along with damage to muscle cells, peripheral axonal polyneuropathy can manifest itself through stabbing pain and general weakness. Muscular neuropathy sometimes occurs in patients using this drug for a long time to prevent gout, as well as in patients with mild kidney failure. Slowing down of bone marrow activity: it is possible to reduce the level of platelets and neutrophil cells up to aregenerative anemia. In rare cases, there may be a danger to life. Shock: manifests itself in oliguria, hematuria, convulsions and disturbance of consciousness. High mortality rate, often in older people. Phlebitis, cellulitis: often observed at the site of intravenous injection. Teratogenic effect: in the literature there are 2 examples of the development of Down syndrome in children whose fathers took this drug for the treatment of hereditary brucellosis. Others: baldness, skin rash, fever, liver damage, etc. Attention! This drug is not a dietary supplement.